Jewell Loyd scored 23 points, Kayla McBride added 18 and second-ranked Notre Dame opened a 33-point halftime lead Sunday en route to a 101-64 victory over Syracuse to improve to 23-0, matching the best start in school history.
Notre Dame took control from the start, beating the Syracuse zone inside and outside, jumping to a 14-2 lead, extending it to 29-10 midway through the first half and 61-28 at halftime.
The other time the Irish (10-0 Atlantic Coast Conference) started 23-0 was in 2000-01 en route to the national championship.
Brittney Sykes led the Orange (17-7, 6-5) with 14 points.
Irish coach Muffet McGraw (737-258) tied the late North Carolina State coach Kay Yow for 11th place in career wins. Yow died in 2009 after a long battle with breast cancer. The Irish and Orange wore pink as part of the Play4Kay game raising awareness of cancer research.